SnapShot: Motile Cilia
نویسندگان
چکیده
منابع مشابه
Sensory reception is an attribute of both primary cilia and motile cilia.
A recent cluster of papers has shown that motile cilia in the respiratory and reproductive tracts of humans and other mammals can exhibit sensory functions, a function previously attributed primarily to non-motile primary cilia. This leads to a new paradigm that all cilia and flagella (both motile and primary) can mediate sensory functions. However, examination of the literature shows that evid...
متن کاملIon channels and calcium signaling in motile cilia
The beating of motile cilia generates fluid flow over epithelia in brain ventricles, airways, and Fallopian tubes. Here, we patch clamp single motile cilia of mammalian ependymal cells and examine their potential function as a calcium signaling compartment. Resting motile cilia calcium concentration ([Ca2+] ~170 nM) is only slightly elevated over cytoplasmic [Ca2+] (~100 nM) at steady state. Ca...
متن کاملCilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear.
Ciliary motility is necessary for many developmental and physiological processes in animals. In zebrafish, motile cilia are thought to be required for the deposition of otoliths, which comprise crystals of protein and calcium carbonate, on hair cells of the inner ear. The identity of the motile cilia and their role in otolith biogenesis, however, remain controversial. Here, we show that the ear...
متن کاملSignaling the differences between cilia.
Calcium ion channels that determine many of the properties of cilia are different in motile cilia as compared to primary cilia and flagella.
متن کاملEvolutionarily Ancient Association of the FoxJ1 Transcription Factor with the Motile Ciliogenic Program
It is generally believed that the last eukaryotic common ancestor (LECA) was a unicellular organism with motile cilia. In the vertebrates, the winged-helix transcription factor FoxJ1 functions as the master regulator of motile cilia biogenesis. Despite the antiquity of cilia, their highly conserved structure, and their mechanism of motility, the evolution of the transcriptional program controll...
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عنوان ژورنال:
- Cell
دوره 162 شماره
صفحات -
تاریخ انتشار 2015